Noticias

Cyp2j4 deletion in rats offers a simplified genetic landscape as opposed to the mice locus, which is under significant allelic expansion.

Under different metabolic stresses (aging, cafeteria diet), Cyp2j4^−/− rats show an accelerated adipogenesis, which progress towards adipocyte dysfunction.

Adipocyte dysfunction in Cyp2j4^−/− rats under cafeteria diet (CAF) is characterised by down-regulation of white adipose tissue (WAT) PPARγ and C/EBPα, adipocyte hypertrophy and extracellular matrix remodeling.

Cyp2j4^−/− rats treated with CAF display exacerbated weight gain, insulin resistance, hepatic lipid accumulation and dysregulated gluconeogenesis.

Cyp2j4^−/− rats display alternative arachidonic acid pathway usage in their adipose tissue upon CAF and aging.