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New paper published in Molecular Nutrition and Food Research
Our work entitled "Subchronic treatment with grape-seed phenolics inhibits ghrelin production despite a short-term stimulation of ghrelin secretion produced by bitter-sensing flavanols" authored by Joan Serrano, Àngela Casanova-Martí, Inge Depoortere, M Teresa Blay, Ximena Terra, Montserrat Pinent and Anna Ardévol has just been published on-line in the Molecular Nutrition and Food Research Journal.
In this study we describe the short-term and long-term effects of GSPE on ghrelin secretion in vivo in rats and ex vivo in rat intestinal segments. A murine ghrelinoma cell line was used to study the effects of GSPE and the main pure phenolic compounds of GSPE on ghrelin release. Pure phenolic compounds were eventually studied in rats and rat intestinal segments to confirm the effects. Since monomeric flavanols are agonists of the bitter receptors hTAS2R14 and hTAS2R39, we used ghrelinoma cells to test the hypothesis that bitter-taste signaling is involved in the flavanol-mediated effects on ghrelin release.
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MoBioFood Research Group published a new paper in the journal Disease Models and Mechanisms
Our work entitled "Identification of a nutrient sensing transcriptional network in monocytes by using inbred rat models of cafeteria diet" authored by N. Martínez-Micaelo, N. González-Abuín, X. Terra, A. Ardévol, M. Pinent, E. Petretto, J. Behmoaras and M. Blay has just been published on-line in the Disease Models and Mechanisms Journal. This publication is the result of a collaboration between MoBioFood and Inflammation Research Group at Imperial College in London. -
Recently published paper in Food and Function: "Dietary fatty acid composition is sensed by the NLRP3 inflammasome"
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Predoctoral grant available at MoBioFood Research Group
The research Group has a predoctoral grant available as part of the Martí i Franquès Programme of Research Grants from the Rovira i Virgili University.
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MoBioFood attended to NutriTech final symposium (Lisbon, Portugal)
The goal of NutriTech is to quantify the effect of diet on "phenotypic flexibility". Phenotypic flexibility extends on metabolic flexibility (the capacity to adapt fuel oxidation to fuel availability) and includes all underlying mechanisms and physiological processes of adaptation when homeostasis is challenged. Methods will in the first instance be evaluated within a human intervention study, and the resulting optimal methods will be validated in a number of existing cohorts against established endpoints.
In doing so, we evaluate the use of cutting-edge analytical technologies and methods to study the diet-health relationship and critically assess their usefulness for the future of nutrition research and human well-being. Technologies include genomics, transcriptomics, proteomics, metabolomics, laser scanning cytometry, NMR based lipoprotein profiling and advanced imaging by MRI/MRS.
NutriTech is a consortium of 23 Partners including 6 non-EU groups .Together, we will disseminate the harmonised and integrated technologies on a global scale and by providing an integrated and standardised data storage and evaluation platform.
The impact of NutriTech will be multifold and exploitation is crucial as major breakthroughs from our technology and research are expected. Overall, NutriTech will lay the foundations for successful integration of emerging technologies intro nutrition research. -
Degree students in MoBioFood Research Group Course 2015-16
Degree students from our University have been working in MoBioFood Research Group as part of their degree training. Thank you all for the good work done!!!
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MoBioFood published a book chapter describing the flavonoid interaction with the gastrointestinal tract
The book is entitled "Grape Seeds: Nutrient Content, Antioxidant Properties and Health Benefits". Nova Publishers New York.
Chapter 3: Flavonoids Interaction with Gastrointestinal Tract: Modulation of Enteroendocrine System, Intestinal Permeability and Metabolic Endotoxemia.
This chapter is focused on how flavonoids could modulate the body homeostasis acting directly on the gastrointestinal tract, explaining their effects on obesity-related pathologies.
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The research group published a research paper in the European Journal of Nutrition
Our main aim in this work was to define the most effective satiating doses of GSPE that could be used to reduce body weight gain.
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MoBioFood participated in the XXV Catalan Society of Digestology Congress celebrated in Reus
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MoBioFood's Ussing Chambers in use!
